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SUMO conjugation regulates the activity of the Integrator complex.
Bragado L, Magalnik M, Mammi P, Romero A, Gaioli N, Pozzi B, Srebrow A. Bragado L, et al. Nucleic Acids Res. 2022 Nov 28;50(21):12444-12461. doi: 10.1093/nar/gkac1055. Nucleic Acids Res. 2022. PMID: 36454007 Free PMC article.
RNA polymerase II (RNAPII) transcribes small nuclear RNA (snRNA) genes in close proximity to Cajal bodies, subnuclear compartments that depend on the SUMO isopeptidase USPL1 for their assembly. We show here that overexpression of USPL1 as well as of another nuclear …
RNA polymerase II (RNAPII) transcribes small nuclear RNA (snRNA) genes in close proximity to Cajal bodies, subnuclear compartments that depe …
Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes.
Doherty LM, Mills CE, Boswell SA, Liu X, Hoyt CT, Gyori B, Buhrlage SJ, Sorger PK. Doherty LM, et al. Elife. 2022 Jun 23;11:e72879. doi: 10.7554/eLife.72879. Elife. 2022. PMID: 35737447 Free PMC article.
The data in this paper are browsable online in a newly developed DUB Portal and promise to improve understanding of DUBs as a family as well as the activities of incompletely characterized DUBs (e.g. USPL1 and USP32) and those already targeted with investigational cancer t …
The data in this paper are browsable online in a newly developed DUB Portal and promise to improve understanding of DUBs as a family as well …
Native Semisynthesis of Isopeptide-Linked Substrates for Specificity Analysis of Deubiquitinases and Ubl Proteases.
Zhao Z, O'Dea R, Wendrich K, Kazi N, Gersch M. Zhao Z, et al. J Am Chem Soc. 2023 Sep 27;145(38):20801-20812. doi: 10.1021/jacs.3c04062. Epub 2023 Sep 15. J Am Chem Soc. 2023. PMID: 37712884 Free PMC article.
We employed these reagents for the investigation of substrate specificities of human UCHL3, USPL1, USP2, USP7, USP16, USP18, and USP36. Pronounced selectivity of USPL1 for SUMO2/3 over SUMO1 was observed, which we rationalize with crystal structures and biochemical …
We employed these reagents for the investigation of substrate specificities of human UCHL3, USPL1, USP2, USP7, USP16, USP18, and USP3 …
Structural basis for the SUMO protease activity of the atypical ubiquitin-specific protease USPL1.
Li Y, Varejão N, Reverter D. Li Y, et al. Nat Commun. 2022 Apr 5;13(1):1819. doi: 10.1038/s41467-022-29485-0. Nat Commun. 2022. PMID: 35383180 Free PMC article.
Here, we present the crystal structure of USPL1 bound to SUMO2, defining the key structural elements for the unusual deSUMOylase activity of USPL1. We identify specific contacts between SUMO2 and the USPL1 subdomains, including a unique hydrogen bond network …
Here, we present the crystal structure of USPL1 bound to SUMO2, defining the key structural elements for the unusual deSUMOylase acti …
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions.
Schulz S, Chachami G, Kozaczkiewicz L, Winter U, Stankovic-Valentin N, Haas P, Hofmann K, Urlaub H, Ovaa H, Wittbrodt J, Meulmeester E, Melchior F. Schulz S, et al. EMBO Rep. 2012 Oct;13(10):930-8. doi: 10.1038/embor.2012.125. Epub 2012 Aug 10. EMBO Rep. 2012. PMID: 22878415 Free PMC article.
C13orf22l--an essential but distant zebrafish homologue of USPL1--also acts on SUMO, indicating functional conservation. We have identified invariant USPL1 residues required for SUMO binding and cleavage. USPL1 is a low-abundance protein that colocalizes with …
C13orf22l--an essential but distant zebrafish homologue of USPL1--also acts on SUMO, indicating functional conservation. We have iden …
A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II.
Hutten S, Chachami G, Winter U, Melchior F, Lamond AI. Hutten S, et al. J Cell Sci. 2014 Mar 1;127(Pt 5):1065-78. doi: 10.1242/jcs.141788. Epub 2014 Jan 10. J Cell Sci. 2014. PMID: 24413172 Free PMC article.
However, a cellular function for USPL1 is so far unknown. Here, we use RNAi-mediated knockdown in human cells in combination with biochemical and fluorescence microscopy approaches to investigate the function of USPL1 and its link to Cajal bodies. ...Thus, our data …
However, a cellular function for USPL1 is so far unknown. Here, we use RNAi-mediated knockdown in human cells in combination with bio …
Expression and Prognosis Analysis of SUMOylation Regulators in Oral Squamous Cell Carcinoma Based on High-Throughput Sequencing.
Meng Y, Li X. Meng Y, et al. Front Genet. 2021 Jun 29;12:671392. doi: 10.3389/fgene.2021.671392. eCollection 2021. Front Genet. 2021. PMID: 34267779 Free PMC article.
RESULTS: RANBP2 and SENP6 had the highest SNV frequency. Eleven genes including PIAS3, RANBP2, USPL1, SENP6, SENP2, SENP5, SAE1, UBA2, PIAS4, UBE2I, and SENP3 were highly expressed in OSCC. ...
RESULTS: RANBP2 and SENP6 had the highest SNV frequency. Eleven genes including PIAS3, RANBP2, USPL1, SENP6, SENP2, SENP5, SAE1, UBA2 …
SUMOylation Regulator-Related Molecules Can Be Used as Prognostic Biomarkers for Glioblastoma.
Li X, Meng Y. Li X, et al. Front Cell Dev Biol. 2021 Apr 9;9:658856. doi: 10.3389/fcell.2021.658856. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33898460 Free PMC article.
RESULTS: Single-nucleotide variant mutations were found in SENP7, SENP3, SENP5, PIAS3, RANBP2, USPL1, SENP1, PIAS2, SENP2, and PIAS1. Moreover, UBE2I, UBA2, PIAS3, and SENP1 were highly expressed in glioblastoma, whereas PIAS1, RANBP2, SENP5, and SENP2 were downregulated i …
RESULTS: Single-nucleotide variant mutations were found in SENP7, SENP3, SENP5, PIAS3, RANBP2, USPL1, SENP1, PIAS2, SENP2, and PIAS1. …
Meta-Analysis of Heat-Stressed Transcriptomes Using the Public Gene Expression Database from Human and Mouse Samples.
Yonezawa S, Bono H. Yonezawa S, et al. Int J Mol Sci. 2023 Aug 30;24(17):13444. doi: 10.3390/ijms241713444. Int J Mol Sci. 2023. PMID: 37686255 Free PMC article.
The results identified previously overlooked genes, such as ABHD3, ZFAND2A, and USPL1, as commonly upregulated genes. Further functional analysis of these genes can contribute to coping with climate change and potentially lead to technological advancements....
The results identified previously overlooked genes, such as ABHD3, ZFAND2A, and USPL1, as commonly upregulated genes. Further functio …
Identification of New Genes and Genetic Variant Loci Associated with Breast Muscle Development in the Mini-Cobb F2 Chicken Population Using a Genome-Wide Association Study.
He Y, Shi H, Li Z, Kang J, Li M, Liu M, Liu Y, Zhao J, Dou T, Jia J, Duan Y, Wang K, Ge C. He Y, et al. Genes (Basel). 2022 Nov 18;13(11):2153. doi: 10.3390/genes13112153. Genes (Basel). 2022. PMID: 36421827 Free PMC article.

After grouping the F2 population according to partial SNPs, significant differences in breast muscle weight were found among different genotypes (p < 0.05), and the expression levels of ALOX5AP, USPL1, CHRNA9, and EFNA5 among candidate genes were also significantly diff

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After grouping the F2 population according to partial SNPs, significant differences in breast muscle weight were found among different genot …
13 results